Disparity in Knowledge of Genetic Testing in Head and Neck Cancer (2025-2026)
This team investigated why Black patients with head and neck cancer often have worse outcomes than white patients. The project explored whether differences in tumors, along with barriers to genetic testing, may contribute to those unequal outcomes. The team reviewed existing research, analyzed patient data and gathered feedback from patients and health care providers to better understand how genetic testing is used and how it can become more accessible and effective for all patients.
The team conducted systematic literature reviews and analyses of clinical data to examine how genetic testing and precision medicine are currently used to treat head and neck cancer. Team members evaluated biomarkers, targeted therapies, next-generation sequencing and genetic mutations linked to patient outcomes. As new findings emerged during the project, the team expanded its research to include additional approaches, such as studying how metabolic therapies may influence disease progression and survival.
The research has resulted in several manuscripts under review for publication. Four student team members received a Bass Connections Student Research Award to continue investigating immune-related adverse events in head and neck cancer, extending the project's impact beyond its initial year. By advancing knowledge of precision medicine and identifying barriers to equitable genetic testing, the team's work supports future efforts to improve cancer care and reduce racial disparities in head and neck cancer outcomes.
Timing
Summer 2025 – Summer 2026
Team Outputs
Precision Medicine in Head and Neck Cancer: Exploring Person-Centered Care from Multiple Perspective (Poster presentation at the Fortin Foundation Bass Connections Showcase, April 15, 2026)
Toxicity Without Equity: Immune-Related Adverse Events in Head and Neck Cancer Immunotherapy (2026 Bass Connections Student Research Award winner)
Disparity in Knowledge of Genetic Testing Reflection (Team profile)
Publications under review at academic journals
Poster presentation (Duke Cancer Institute Cancer Control and Prevention Poster Fair; Durham, N.C.; May, 2026)
Poster presentation (Duke Head and Neck Surgery and Communication Sciences Alumni Research Day; Durham, N.C.; June, 2026)