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Discovering AI Applications for Traumatic Brain Injury Care (2024-2025)

The team examined how artificial intelligence (AI) can improve the management of traumatic brain injury (TBI), a leading cause of death and disability in the United States. Because TBI cases are highly variable and difficult to treat, the team sought to identify opportunities for AI to support clinical decision-making and patient care. To do so, students combined qualitative research, including interviews and shadowing across the Duke Health system, with quantitative analysis of electronic health records (EHRs) to inform the development of potential AI applications.

Through 28 clinician interviews across the emergency department, ICU, surgical units, and hospital floors, the team identified critical gaps in care that AI could help address. Providers highlighted opportunities for AI to triage patients in the ED, predict individualized prognoses earlier in the ICU, guide surgical interventions with better longitudinal data, and improve discharge education for families. These findings were compiled into an interactive application that maps the TBI care pathway. At the same time, students gained hands-on training in qualitative methods and clinical shadowing, deepening their understanding of how care is delivered at multiple points in the pathway.

On the quantitative side, the team worked with deidentified EHR data from Duke hospitals to prepare it for future AI modeling. Students cleaned and assessed datasets across demographics, labs, medications, and radiology reports, applying a quality assurance framework and validating usability with clinical champions. Their efforts yielded tools such as an algorithm for processing radiology text, visualizations of patient movement through care, and demographic analyses to detect bias. Together, the qualitative and quantitative tracks laid the groundwork for ethical, clinically relevant AI models that could enhance TBI care and potentially inform open-source research in the field.

Timing

Fall 2024 – Spring 2025

Team Outputs

Discovering AI Applications for TBI Care (Poster presentation at the Fortin Foundation Bass Connections Showcase, April 16, 2025)

Interactive application for TBI care pathways

Developed an organized codebase to carry out data cleaning

Algorithm for removing unwanted text from radiology reports

Sankey diagrams to visualize patient movement through care

Demographic analyses to detect bias

 

Image: Gene Activity After TBI, by Douglas Arneson and Drs. Gomez-Pinilla and Yang, UCLA, NIH Image Gallery, licensed under CC BY-NC 2.0  

Team Leaders

  • Samuel Berchuck, Arts & Sciences: Statistical Science, School of Medicine: Biostatistics and Bioinformatics
  • Bradley Kolls, School of Medicine: Neurology
  • Brian Lerner, Pratt School of Engineering–Ph.D. Student
  • Pranav Manjunath, Pratt School of Engineering: Biomedical Engineering

Graduate Team Members

  • Katelyn Hucker, Data Science - MS
  • Yesel Trillo-Ordonez, Global Health - MS
  • Aparnaa Velayudhan, Global Health - MS

Undergraduate Team Members

  • Colin Belton, Neuroscience (BS)
  • Sophie Cary, Psychology (BS)
  • Ana Despa, Biomedical Engineering (BSE)
  • Carl Dong, Computer Science (BS); Mathematics (AB2)
  • Daniel Elsharkawy, Biomedical Engineering (BSE); Computer Science (BS2)
  • Akhil Eraniyan, Evolutionary Anthropology (BS)
  • Millie Evonlah, Neuroscience (BS)
  • Chisom Ezigbo, Psychology (BS)
  • Zakk Heile, Mathematics (BS); Computer Science (BS2)
  • Maya Hoteit, Biology (BS)
  • Lucy Kopin, Computer Science (BS)
  • Michelle Moon, Biology (BS); Neuroscience (AB2)
  • Keon Nartey
  • Blake Passe, Computer Science (BS)
  • Dylan Rosen, Neuroscience (BS)
  • Sophia Saxonhouse, Biomedical Engineering (BSE)
  • Lena Wang, Electrical & Computer Egr(BSE); Computer Science (BS2)
  • Vivienne Wluka, Neuroscience (BS)
  • Eddie Zhou, Computer Science (BS)

Team Contributors

  • Michael Cary, School of Nursing
  • Timothy Dunn, Pratt School of Engineering: Biomedical Engineering, School of Medicine: Neurosurgery
  • Deborah Koltai, School of Medicine: Neurology, School of Medicine: Psychiatry and Behavioral Sciences
  • Tolulope Oyesanya, School of Nursing
  • Karin Reuter-Rice, School of Nursing