Oculomotor Response as an Objective Assessment for Mild TBI in the Pediatric Population (2018-2019)
In children, brain injury is complex and common, and currently it is a leading source of injury and death. Sports-related concussions in children and adolescents (5-18 years) account for 30-60% of all pediatric concussions.
Though mild traumatic brain injury (mTBI) is an important public health issue for both the general pediatric population and youth athletes, challenges exist in obtaining objective diagnoses of mTBI or quantifying the physiological implications of cumulative subconcussive (low-level) insults.
Establishing a link between the clinical diagnoses and objective diagnostic tools that are sensitive over a spectrum of pathophysiology that includes the minimally sub-concussed child to those that experience many subconcussive events or are clinically diagnosed with a concussion are crucial in developing mitigation strategies.
To bridge this gap, this Bass Connections project will assess youth athletes with an oculomotor assessment routine that includes reflexive (pro-saccades), anti-saccades and memory-guided saccades, and compare these data to in-season documentation of concussion and level of impact/practice exposure. The sample population will include youth athletes from five years of age to the high school level. This will be Year 4 of an ongoing study.
Multiple age levels and levels of play will be assessed. Changes in oculomotor response when compared to documented injury will be assessed as an objective tool for diagnosing concussion and quantifying the pathophysiology of cumulative subconcussive insults to the pediatric brain.
The fall semester will include extensive off-site work associated with assessments and DASHR data collection, while the spring semester and summer bring a focus on data analysis and involve weekly team meetings and sub-group meetings associated with specific data set analysis.
Manuscripts, abstracts, presentations or posters at a local conference (UNC Chapel Hill)
Spring 2018 – Spring 2019
- Spring 2018: Amendments to IRB protocols completed, submitted and iterated; new team members integrated into 2017-18 team activities as schedules allow
- Summer 2018: Current oculomotor assessments revisited and any technical changes addressed; youth league oculomotor instructional video revisited for potential improvements; progress toward increased portability of existing in-house oculomotor test setup; out-of-season oculomotor assessment; orientation meeting with coaches, parents/guardians and athletes; July/August baseline and follow-up Year 4 oculomotor assessment and DASHR fitting/deployment; DASHR participants molded for personalized earpieces and deployed for pre-season practice
- Fall 2018: Analysis of oculomotor assessments, baseline through end-of-season
- Spring 2019: Out-of-season oculomotor assessment
Team Outcomes to Date
Standardized Assessment of Concussion (SAC) Score Stability: Comparing across a High School Football Season – A Pilot Study (poster by Alexandra F. Putka, Varun Nukala, Wesley J. Pritzlaff, Beau M. Blass, Mitchell Z. Abrams, Mihir Paithane, Connor Hile, Edward Hsieh, Katya Khlystova, Cameron R. Bass, Jason F. Luck, presented at Bass Connections Showcase, Duke University, April 17, 2019)
Eye-tracking and Subconcussive Loading: Changes in Objective Oculomotor Task Metrics Following Head Impact Exposure in a High School Football Season – A Pilot Study (poster by Wesley J. Pritzlaff, Beau M. Blass, Mitchell Z. Abrams, Mihir Paithane, Connor Hile, Edward Hsieh, Katya Khlystova, Adam Mehlenbacher, Bruce Capehart, Cameron R. Bass, Jason F. Luck, presented at Bass Connections Showcase, Duke University, April 17, 2019)
Quantifying Head Impact Exposure in High School Football Using a Novel Weekly Athletic Exposure Form – A Pilot Study (poster by Beau M. Blass, Varun Nukala, Wesley J. Pritzlaff, Alexandra F. Putka, Lydia R. Smeltz, Joyce Zhou, Cameron R. “Dale” Bass, Jason F. Luck, presented at Bass Connections Showcase, Duke University, April 17, 2019)
Measuring Head Impact Exposure with In-Ear Sensing Devices and Development of Tools for Data Analysis – A Pilot Study (poster by Patrick Liu, Mitchell Z. Abrams, Kyle A. Matthews, BSE, Adam Mehlenbacher, Jason Kait, Cameron R. “Dale” Bass, Jason F. Luck, presented at Bass Connections Showcase, Duke University, April 17, 2019)
See related teams, Oculomotor Response as an Objective Assessment for Mild TBI in the Pediatric Population (2019-2020) and Oculomotor Response as an Objective Assessment for Mild TBI in the Pediatric Population (2017-2018).
- Cameron Bass, Pratt School of Engineering-Biomedical Engineering
- Bruce Capehart, School of Medicine-Psychiatry and Behavioral Sciences
- Jennifer Groh, Arts & Sciences-Psychology and Neuroscience
- Jason Luck, Pratt School - Biomedical Engineering
- Adam Mehlenbacher, School of Medicine-Surgery: Otolaryngology - Head and Neck Surgery
- Carrie Muh, School of Medicine-Neurosurgery
/graduate Team Members
Joost Op 't Eynde, Biomedical Engineering-MS, Biomedical Engineering-PHD
/undergraduate Team Members
Mitchell Abrams, Biomedical Engineering (BSE)
Beau Blass, Neuroscience (BS)
Ekaterina Khlystova, Chemistry (BS), Linguistics (AB2)
Patrick Liu, Electrical & Computer Egr(BSE), Computer Science (BSE2)
Varun Nukala, Neuroscience (BS)
Wesley Pritzlaff, Neuroscience (BS), Computer Science (AB2)
Alexandra Putka, Biology (BS)
Lydia Smeltz, Chemistry (AB)
Joyce Zhou, Electrical & Computer Egr(BSE), Computer Science (BSE2)
/yfaculty/staff Team Members
Connor Hile, Duke Institute for Brain Sciences
Jason Kait, Pratt School of Engineering-Biomedical Engineering
/zcommunity Team Members
Cardinal Gibbons High School
Durham Eagles Pop Warner Youth Football
Raleigh Revolution Middle School Youth Football