Bioremediating Plastic Pollution to Conserve Marine Biodiversity (2021-2022)
By 2025, we may be throwing away over 2.2 billion tons of plastics each year. Sadly, much of this plastic ends up in our oceans. Ingestion of plastics by marine species has a substantial negative impact on their health, and plastic bioaccumulation in fish can even transmit carcinogens up the food chain to our dinner plates.
Yet, despite the staggering volume of debris produced annually and the clear environmental and human health impacts, plastic waste continues to accumulate. There is an urgent need to better understand the impact of plastic on organisms and develop novel strategies to combat bioaccumulation of plastics.
The aim of this research team was to demystify the health effects of plastic additives and validate lab-grown plastic biodegrading organisms. To tackle these goals, team members tested the carcinogenic potential of selected additives with unknown classification; identified specific genes and pathways impacted by additives to clarify how additives affect human health; depicted relations between additives of known carcinogenicity and understudied, ill-documented additives; underlined gaps between genes that are most studied and most salient to the toxic effects of additives; tested newly identified enzymes capable of rapidly degrading plastic; and found new plastic-degrading enzymes testable in the lab.
Ultimately, this team hopes that their efforts will help prevent and mitigate the harmful effects of plastic bioaccumulation.
Learn more about this project team by viewing their lightning talk at the 2022 Fortin Foundation Bass Connections Showcase.
Summer 2021 – Summer 2022
Understanding and Reducing the Harmful Effects of Plastic (2022 Fortin Foundation Bass Connections Virtual Showcase)
Plastic Additives: Understanding Threats to Human Health and Bioremediation Strategies (poster by Rita Glazer, Alex Hong, Sophia Vincoff, Newland Zhang, Jas Santos, Hailey Brighton, Sarah Plumlee and Jason A. Somarelli, presented at Fortin Foundation Bass Connections Showcase, Duke University, April 13, 2022)
Bioremediation of Plastic Pollution to Conserve Marine Biodiversity (Ella Gunady and Beatrice Schleupner, lightning talk at Fortin Foundation Bass Connections Showcase, Duke University, April 13, 2022)
Margaret Morrison, Rafael Trevisan, Prabha Ranasinghe, Greg B. Merrill, Jasmine Santos, Alexander Hong, William C. Eward, Nishad Jayasundara, Jason A. Somarelli. "A Growing Crisis for One Health: Impacts of Plastic Pollution Across Layers of Biological Function." 2022. Frontiers in Marine Science vol. 9.
Sophia Vincoff, Beatrice Schleupner, Jasmine Santos, Margaret Morrison, Newland Zhang, Meagan M. Dunphy-Daly, William C. Eward, Andrew J. Armstrong, Zoie Diana, Jason A. Somarelli. "Toxicogenomic Analysis of the Carcinogenic Potential of Plastic Additives." 2023. Preprint.
This Team in the News
See related teams, Bioremediation of Plastic Pollution to Conserve Marine Biodiversity (2022-2023) and Bioremediation of Plastic Pollution to Conserve Marine Biodiversity (2020-2021).
Image: Marine litter (a discarded plastic bottle, stranded), by Bo Eide, licensed under CC BY-NC-ND 2.0
- Meagan Dunphy-Daly, Nicholas School of the Environment-Marine Science and Conservation
- William Eward, School of Medicine-Orthopaedic Surgery
- Thomas Schultz, Nicholas School of the Environment-Marine Science and Conservation
- Jason Somarelli, School of Medicine-Medicine: Medical Oncology
/graduate Team Members
Greg Merrill, Ecology-PHD
Margaret Morrison, Master of Environmental Management, Coastal Environmental Management, Geospatial Analysis
/undergraduate Team Members
Rita Glazer, Computer Science (AB)
Ella Gunady, Biomedical Engineering (BSE)
Alexander Hong, Interdepartmental Major
Jasmine Santos, DKU Interdisciplinary Studies (BS)
Beatrice Schleupner, Biology (BS)
Serafina Turner, Computer Science (BS)
Sophie Vincoff, Biomedical Engineering (BSE)
Newland Zhang, Biomedical Engineering (BSE)
/yfaculty/staff Team Members
Hailey Brighton, School of Medicine-Orthopaedic Surgery
Sarah Plumlee, School of Medicine-Orthopaedic Surgery
Andrew Read, Nicholas School of the Environment-Marine Science and Conservation
/zcommunity Team Members
Durham Public Schools, City of Medicine Academy
North Carolina Museum of Natural Sciences
East Durham Children's Initiative
Environmental Science Summer Program
Duke University Marine Lab
Nicholas Institute for Enviornmental Policy Solutions